![]() The ability of taurine to conjugate with xenobiotics, retinoic acid, and bile salts and its role as a major free amino acid in regulating the osmolality of cells are also examples of protective functions. Taurine stabilises membranes, modulates calcium transport, and is able to dissipate the toxic effects of hypochlorous acid (HOCl) by the formation of the relatively stable taurochloramine molecule, generated by myeloperoxidases from oxygen radicals. The diet provides most taurine either directly or by synthesis in the liver and brain from methionine or cysteine via cysteic acid or hypotaurine or via cysteamine in the heart and kidney. Taurine, a sulfur-containing amino acid, is a relatively nontoxic substance and a normal constituent of the human diet. Since taurine is occasionally used in therapeutics as a medicine, the pharmacokinetics and effects of oral taurine in healthy volunteers would be useful in the future studies of taurine in pharmacology and nutrition. Plasma elimination half-life ( ) and the ratio of clearance/bioavailability (Cl/F) were hr and L/hr, respectively. Maximum plasma taurine concentration ( ) was measured at hr after administration as mg/L ( mmol). Data were subjected to noncompartmental analysis. Blood samples were taken at regular intervals and plasma taurine concentration was measured by a modified HPLC method. ![]() We studied the pharmacokinetics of 4 g taurine in eight healthy male volunteers (median age 27.5, range 22–45) following orally administration in the fasting state in the morning. Little is known of the pharmacokinetics of taurine in man after oral administration. Taurine, a sulfur-containing amino acid, is a normal constituent of the human diet.
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